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-synuclein, that is a main part of Lewy bodies, in PARK 1 in 1997 and parkin in PARK 2 in 1998, that is an E3 ubiquitin ligase and triggers endoplasmic reticulum (ER) anxiety, suggest that dysfunction of the intracellular proteinase devices, which include ubiquitin-proteasome program or lysosomal procedure, which eliminates unnecessary harmful prot

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